MyBioSource.com's MBTPS1 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The MBTPS1 Antibody was generated using MBTPS1, and S1p as the antigen and it reacts with Human, Mouse, and Rat.
Description
Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.Nakajima T., J. Hum. Genet. 45:212-217(2000).Nagase T., DNA Res. 2:37-43(1995).Bechtel S., BMC Genomics 8:399-399(2007)